In De Bazan v. Secy of HHS, 539 F.3d 1347 (Fed. Cir. 2008), petitioner alleged her acute disseminated encephalomyelitis (ADEM) occurred eleven hours after her tetanus vaccination. Id. at 1349-50. ADEM is an autoimmune disorder affecting the central nervous system. Id. at 1350, n.1. Petitioner became a quadriplegic. Id. at 1350. The testimony of respondents expert at the hearing concerned the brevity of the eleven-hour onset interval. The special master held that petitioners onset was too soon to be appropriate for vaccine causation. However, a judge on the Court of Federal Claims reversed the special masters dismissal, concluding that petitioner had established a prima facie case. The Federal Circuit reversed, finding no error in the special masters conclusion that an eleven-hour onset was too soon to connote causation. The Federal Circuit stated that a petitioner must provide preponderant proof that the onset of symptoms occurred within a timeframe for which, given the medical understanding of the disorders etiology, it is medically acceptable to infer causation-in-fact. Id. at 1352. Since eleven hours was not sufficient time to produce molecules responsible for myelin destruction, the onset interval in De Bazan was inappropriate for causation. Id. at 1353, 1354.